I've settled on grouping by voice sets, not by having a row of oscillators, a bank of envelopes...
I did that at first, but now my clocks are grouped together up in the left corner, and audio/midi io in the lower left.
But I try to have modules in the middle near each other that I can link with
those little yellow doepfer wires as reasonable "defaults".
I also need less wires using Doepfer's CV and trigger bus lines in three of the groupings.
I sort of see it as: here's my bass and percussion sections, this group does keys, this row is guitar/lead,
and this is the mix to output. I can always cross patch to oblivion, but I don't have to every time I sit down to record.
Oh, and the Doepfer A-180-9 Multicore works great for interconnecting boxes.
My eyes are messed up with strabismus so I get lost in the weeds when wires are draped everywhere.
Not a kid now I guess, but I don't like wire balls anymore like I used to.
I believe neither did Alan R. Perlman's designs, compared to Moog and Buchla.
(latest build plan here)